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Taking high-dose supplements over 1,000 mg per day may also increase the risk of kidney stones in predisposed people ( Benefits of Supplements There is mixed evidence that vitamin C supplements benefit people who get adequate amounts from the diet

Tirzepatide combined with sulfonylureas also elevates risk significantly

Further study showed the patients given saffron also had decreased levels of inflammatory TNF-, increased levels of anti-inflammatory IL-10, and improved quality of life (Heydarian 2022)